Xu Lab at Marshall University Joan C. Edwards School of Medicine

The Xu Lab at Marshall University is a dynamic research group focused on understanding how bacteria cause disease, especially Streptococcus pyogenes and Enterococcus faecalis. We study how these pathogens disrupt the immune system and damage tissue by producing small molecules called short-chain fatty acids (SCFAs). Our team is developing new therapies that block harmful bacterial metabolism and protease activity, with the goal of improving recovery from serious infections and protecting healthy tissue. We also investigate a form of excessive immune response called hyper-NETosis, which plays a key role in shaping how the body fights infection. By connecting basic science with real-world clinical problems, our work aims to advance treatments for antibiotic-resistant infections through innovation and collaboration.